REVIEW ON PATHOGENETIC PROCESSES OF SYSTEMIC LUPUS ERYTHEMATOSUS

Authors

  • Ziyayeva F.K.
  • Djurayeva E.R.
  • Omonov B.X.

Keywords:

Systemic lupus erythematosus, pathogenesis, endothelial dysfunction

Abstract

Systemic lupus erythematosus (SLE) is a particularly significant problem in clinical rheumatology, since the survival rate of this group of patients remains very low. Therefore, all attempts aimed at finding predictors that affect life expectancy in a given disease are of leading importance and this is of practical interest. Pathology of the cardiovascular system, kidneys and central nervous system in SLE is one of the most frequent manifestations of the disease and largely determines its prognosis, and the pathogenetic structures of lesions of the myocardium, coronary, renal and cerebral vessels remain insufficiently studied. SLE is characterized by the development of vasculitis of varying severity. Activation of pro-inflammatory mediators, monocytes, T cells leads to endothelial damage. In recent years, the contribution of endothelial dysfunction (ED) (due to chronic inflammation) to the progression of systemic lupus erythematosus has been discussed.

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Published

2023-02-09