EFFECT OF LAGOVIN ON PLASMA HEMOSTASIS PARAMETERS IN RABBITS ON HYPOCOAGULATION MODEL

Abstract

Hemorrhages or hemorrhages are one of the types of hemostasis pathology. Bleeding can be caused by various disorders of plasma and cellular hemostasis, as well as permeability of the vascular wall [1]. The main causes of bleeding are thrombocytopenias, thrombocytopathies, hereditary disorders of plasma hemostasis, primary, secondary hyperfibrinolysis, acquired coagulopathies and others [2]. Despite the existence of various styptic agents, the problem of stopping bleeding in medicine remains relevant. Despite the achieved successes in the creation of effective and safe styptic agents, physicians, pharmacologists, biochemists face an acute problem of searching and creating new hemostatic agents of general and local action. Deeper studies of lagohilin and its derivatives have shown that in addition to hemostatic action, these compounds have sedative, hypotensive, desensitizing, antispasmodic and antirheumatic effects [3, 4, 5]. It was also found that diterpenoids cause changes in the concentration of intracellular calcium in platelets.