MENOPAUSAL METABOLIC SYNDROME AND THE POSSIBILITY OF PRESCRIBING MENOPAUSAL HORMONE THERAPY

Abstract

The menopausal period is a physiological transition period in a woman's life when there is a gradual decrease and shutdown of ovarian function. It is during this period that menopausal metabolic syndrome (MMS) often develops, which is characterized by an increase in visceral fat mass, insulin resistance and hyperinsulinemia, causing disorders of carbohydrate, lipid, purine metabolism. The article discusses the factors that increase the likelihood of developing menopausal metabolic syndrome and the risks that arise in this case. Diagnostic methods, approaches to the treatment of MMS, the possibilities and features of prescribing menopausal hormone therapy (MНT), the expected effects of it are described. The difficulties of MHT are due to the lack of an optimal drug that would ensure the maintenance of the functions of the cardiovascular system, bone system, brain function, optimal body weight and would have a minimal risk of side effects and complications. At the same time, correctly selected hormonal therapy of menopausal disorders in women in the perimenopausal and early postmenopausal periods is an effective and safe method of prevention and treatment of MMS, which creates prerequisites for the development of cardiovascular diseases and type 2 diabetes mellitus.